作者
Hung-Yang Kuo, Zhong-Zhe Lin, Raymond Kuo, Wen-Yi Shau, Chiu-Lin Lai, Yen-Yun Yang, Yu-Yun Shao, Chiun Hsu, Wen-Fan Cheng, Ann-Lii Cheng, James Chih-Hsin Yang, Mei-Shu Lai
发表日期
2015/9/1
期刊
The oncologist
卷号
20
期号
9
页码范围
1051-1057
出版商
Oxford University Press
简介
Background
Many studies have shown that type 2 diabetes mellitus (DM) increases the risk for several types of cancer but not cervical cancer (CC). Although DM and insulin-like growth factor 1 have preclinical and clinical implications for CC, less is known about the prognostic impact of DM on patients with early stage CC.
Patients and Methods
We used the nationwide Taiwan Cancer Registry database to collect the characteristics of stage I–IIA cervical cancer patients diagnosed between 2004 and 2008. DM and other comorbidities were retrieved from the National Health Insurance database. Cervical cancer-specific survival (CSS) and overall survival (OS) times of patients according to DM status were estimated using the Kaplan-Meier method. We used a Cox proportional hazards model to calculate adjusted hazard ratios (HRs) for the effects of DM and other risk factors on …
学术搜索中的文章
HY Kuo, ZZ Lin, R Kuo, WY Shau, CL Lai, YY Yang… - The oncologist, 2015