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Cancer is a major public health problem of the world. Diagnosis of cancer has a significant impact not only on patient, but also on their family caregivers. Therefore cancer has a substantial impact on both patients and families. Objectives of the study were to assess the Quality of Life (QOL) among caregivers and to find the association between mean score of quality of life of family caregivers with selected variables. A cross sectional study was done among 399 family caregivers those who are providing care to the hospitalized patients with advanced cancer. A non probability purposive sampling was used to select family caregivers by using structured and validated questionnaire on quality of life. Data were collected by interview technique from caregivers. Result shows that majority of family caregivers were in the age group of 20-40yrs (53.6%), most of the family members had to stop working, and most of them lost their savings. Majority of the family caregivers expressed that ‘financial burden’had negative influence on the quality of life. The mean Quality Of Life was 63.36 and SD was 15.73. The present study suggests that to improve QOL of caregivers, measures should be taken to decrease the economic burden that cancer places on patient’s family. It also revealed that increasing the self-confidence of family care givers in managing cancer pain is vital to the quality of life of both the patient and caregiver.