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Since its introduction in 1985, VNTR polymorphism analysis has rapidly become a routine technique for forensic biology and population genetics. But so far there are still some controversies surrounding VNTR polymorphisms, one of them being whether they violate the assumptions of Hardy-Weinberg equilibrium (HWE). Concerning biostatistical tests the only significant difference between VNTR loci analysed by AMP-FLP and traditional serological markers is that there are more alleles at a particular VNTR locus, so that not all genotypes can be observed in a relatively small sample. Therefore, some indirect methods have been suggested to test HWE for these VNTR loci (1–4), but the efficiency of them was not evaluated. Our purpose here is to compare the efficiency of different statistical tests and to suggest a more sensitive new modification.