作者
Ju-Ton Hsieh, Kuan-Lin Kuo, Shing-Hwa Liu, Chung-Sheng Shi, Hong-Chiang Chang, Wei-Chou Lin, Chien-Tso Chou, Chen-Hsun Hsu, Shih-Ming Liao, Zuo-He Wang, Chih-Chien Li, Kuo-How Huang
发表日期
2016/5/1
期刊
Urology
卷号
91
页码范围
242. e1-242. e9
出版商
Elsevier
简介
Objectives
To investigate the protective effect of epigallocatechin gallate (EGCG), a green tea extract, on partial bladder outlet obstruction (pBOO)-induced bladder injury in a rat model.
Methods
The female Sprague-Dawley rats underwent sham or BOO procedures, and were divided into several groups (sham with saline injection, sham with EGCG treatment, BOO with saline injection, and BOO with EGCG treatment). The rats in each group were randomized into 2 groups (48 hours and 30 days after the BOO procedure) for when their bladders were harvested. EGCG (4.5 mg/kg/day) and saline were administered via intraperitoneal injection after the BOO procedure during the study period. Bladder tissue was examined for inflammation, endoplasmic reticulum (ER) stress-related apoptotic markers by Western blot, and histological staining.
Results
BOO induced acute bladder injury (hemorrhage, edema, and neutrophil …
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JT Hsieh, KL Kuo, SH Liu, CS Shi, HC Chang, WC Lin… - Urology, 2016