作者
Olivier Hanon, Jean-Sébastien Vidal, Sylvain Lehmann, Stéphanie Bombois, Bernadette Allinquant, Jean-Marc Tréluyer, Patrick Gelé, Christine Delmaire, Frédéric Blanc, Jean-François Mangin, Luc Buee, Jacques Touchon, Jacques Hugon, Bruno Vellas, Evelyne Galbrun, Athanase Benetos, Gilles Berrut, Elena Paillaud, David Wallon, Giovanni Castelnovo, Lisette Volpe-Gillot, Marc Paccalin, Philippe-Henri Robert, Olivier Godefroy, Thierry Dantoine, Vincent Camus, Joël Belmin, Pierre Vandel, Jean-Luc Novella, Emmanuelle Duron, Anne-Sophie Rigaud, Suzanna Schraen-Maschke, Audrey Gabelle, Frédéric Blanc, Yasmina Boudali, Marie–Laure Seux, Hermine Lenoir, Catherine Bayle, Xavier Delbeuck, Florence Moulin, Florence Latour, Matthieu Plichart, Sophie Pichierri, Galdric Orvoën, Lisette Volpe–Gillot, Florien Labourée, Pascaline Cassagnaud, Claire Paquet, Françoise Lala, Julien Dumurgier, Anne–Sophie Rigaud, Christine Perret–Guillaume, Eliana Alonso, Foucaud du Boisgueheneuc, Laurence Hugonot–Diener, Adeline Rollin–Sillaire, Olivier Martinaud, Clémence Boully, Yann Spivac, Agnès Devendeville, Philippe–Henri Robert, Laure Caillard, Didier Hannequin, Nathalie Sastre, Sophie Haffen, Anna Kearney–Schwartz, Jean–Luc Novella, Vincent Deramecourt, Valérie Chauvire, Gabiel Abitbol, Nathalie Schwald, Caroline Hommet, François Sellal, Marie–Ange Cariot, Mohamed Abdellaoui, Sarah Benisty, Salim Gherabli, Pierre Anthony, Frédéric Bloch, Nathalie Charasz, Sophie Chauvelier, Jean–Yves Gaubert, Guillaume Sacco, Olivier Guerin, Jacques Boddaert, Marie–Anne Mackowiak, Marie–Thérèse Rabus, Valérie Gissot, Candice Picard, Céline Guillemaud, Claire Gervais, Jaques Hugon, Jean–Marc Michel, Jean–Philippe David, Marion Paulin, Pierre–Jean Ousset, Sylvie Pariel, Anne Chawakilian, Léna Joffredo, Anne–Cécile Troussiere, Cécile Adam, Diane Dupuy, Hélène Briault, Isabelle Saulnier, Karl Mondon, Marie–Agnès Picat, Marie Laurent, Rezki Daheb, Stéphanie Libercier, Djamila Krabchi, Marie Chupin, Jean–Sébastien Vidal, Edouard Chaussade
发表日期
2018/7/1
期刊
Alzheimer's & Dementia
卷号
14
期号
7
页码范围
858-868
出版商
No longer published by Elsevier
简介
Introduction
Diagnostic relevance of plasma amyloid β (Aβ) for Alzheimer's disease (AD) process yields conflicting results. The objective of the study was to assess plasma levels of Aβ42 and Aβ40 in amnestic mild cognitive impairment (MCI), nonamnestic MCI, and AD patients and to investigate relationships between peripheral and central biomarkers.
Methods
One thousand forty participants (417 amnestic MCI, 122 nonamnestic MCI, and 501 AD) from the Biomarker of AmyLoïd pepTide and AlZheimer's diseAse Risk multicenter prospective study with cognition, plasma, cerebrospinal fluid (CSF), and magnetic resonance imaging assessments were included.
Results
Plasma Aβ1–42 and Aβ1–40 were lower in AD (36.9 [11.7] and 263 [80] pg/mL) than in amnestic MCI (38.2 [11.9] and 269 [68] pg/mL) than in nonamnestic MCI (39.7 [10.5] and 272 [52] pg/mL), respectively (P = .01 for overall difference between groups …
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O Hanon, JS Vidal, S Lehmann, S Bombois… - Alzheimer's & Dementia, 2018