作者
Lorraine W Lau, Michael B Keough, Sarah Haylock‐Jacobs, Rowena Cua, Axinia Döring, Scott Sloka, David P Stirling, Serge Rivest, V Wee Yong
发表日期
2012/9
期刊
Annals of neurology
卷号
72
期号
3
页码范围
419-432
出版商
Wiley Subscription Services, Inc., A Wiley Company
简介
Objective
Failure of remyelination is a critical impediment to recovery in multiple sclerosis (MS). Chondroitin sulfate proteoglycans (CSPGs) have been reported to accumulate in MS lesions, and we thus examined the functional roles of CSPGs on oligodendrocyte precursor cells (OPCs), oligodendrocytes, and remyelination.
Methods
We evaluated the expression of CSPGs in lysolecithin‐injected mouse spinal cord, an animal model of demyelination and spontaneous remyelination. The functional impact of CSPGs on OPCs and remyelination was investigated using cultured adult murine and human OPCs and by treating demyelinated mice with xyloside to reduce the CSPG deposition that occurred following injury.
Results
Early and robust upregulation of CSPGs following lysolecithin‐induced demyelination was cleared during remyelination. In culture, CSPGs anchored onto the substratum reduced the adhesion …
学术搜索中的文章
LW Lau, MB Keough, S Haylock‐Jacobs, R Cua… - Annals of neurology, 2012