作者
Ibrahim Danad, Valtteri Uusitalo, Tanja Kero, Antti Saraste, Pieter G Raijmakers, Adriaan A Lammertsma, Martijn W Heymans, Sami A Kajander, Mikko Pietilä, Stefan James, Jens Sörensen, Paul Knaapen, Juhani Knuuti
发表日期
2014/10/7
期刊
Journal of the American College of Cardiology
卷号
64
期号
14
页码范围
1464-1475
出版商
American College of Cardiology Foundation
简介
Background
Recent studies have demonstrated improved diagnostic accuracy for detecting coronary artery disease (CAD) when myocardial blood flow (MBF) is quantified in absolute terms, but there are no uniformly accepted cutoff values for hemodynamically significant CAD.
Objectives
The goal of this study was to determine cutoff values for absolute MBF and to evaluate the diagnostic accuracy of quantitative [15O]H2O positron emission tomography (PET).
Methods
A total of 330 patients underwent both quantitative [15O]H2O PET imaging and invasive coronary angiography in conjunction with fractional flow reserve measurements. A stenosis >90% and/or fractional flow reserve ≤0.80 was considered obstructive; a stenosis <30% and/or fractional flow reserve >0.80 was nonobstructive.
Results
Hemodynamically significant CAD was diagnosed in 116 (41%) of 281 patients who fulfilled study criteria for CAD. Resting …
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