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Vitamin C at high concentrations is toxic to cancer cells in vitro. Early clinical studies of vitamin C in patients with terminal cancer suggested clinical benefit, but 2 double-blind, placebo-controlled trials showed none. However, these studies used different routes of administration.

To determine whether plasma vitamin C concentrations vary substantially with the route of administration.

Dose concentration studies and pharmacokinetic modeling.

Academic medical center.

17 healthy hospitalized volunteers.

Vitamin C plasma and urine concentrations were measured after administration of oral and intravenous doses at a dose range of 0.015 to 1.25 g, and plasma concentrations were …