作者
WE Hart, N Krasnogor, DA Pelta, J Smith
发表日期
1999/2/8
期号
SAND99-0329C
出版商
Sandia National Lab.(SNL-NM), Albuquerque, NM (United States); Sandia National Lab.(SNL-CA), Livermore, CA (United States)
简介
Evolutionary algorithms have been successfully applied to a variety of molecular structure prediction problems. In this paper we reconsider the design of genetic algorithms that have been applied to a simple protein structure prediction problem. Our analysis considers the impact of several algorithmic factors for this problem: the confirmational representation, the energy formulation and the way in which infeasible conformations are penalized, Further we empirically evaluated the impact of these factors on a small set of polymer sequences. Our analysis leads to specific recommendations for both GAs as well as other heuristic methods for solving PSP on the HP model.
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WE Hart, N Krasnogor, DA Pelta, J Smith - 1999