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Background

Oral squamous-cell carcinoma (OSCC) is the most common oral malignancy with a dismal prognosis. Exploring markers predict tumor behavior, help in diagnosis, and therapy is crucial. Actinin alpha 1 (ACTN1) is known to be a prognostic biomarker in acute myeloid leukemia. It also plays a role in many tumors. The epithelial–mesenchymal transition has been suggested as one of the mechanisms of action for ACTN1. The role of ACTN1 in OSCC is still unclear. This study aimed at evaluating the role of ACTN1 in OSCC.

Materials and methods

This study was performed on 68 OSCC cases and 68 normal-tissue samples. Immunohistochemical staining of ACTN1 and E-cadherin was done and evaluated. Correlation to clinicopathologic parameters and survival was statistically analyzed.

Results

ACTN1 expression was high in 47 (69.1%) cases. E-cadherin expression was high in 27 (39.7%) cases with a …