作者
Santiago Diaz-Torres, Weixiong He, Jackson Thorp, Sahba Seddighi, Sean Mullany, Christopher J Hammond, Pirro G Hysi, Louis R Pasquale, Anthony P Khawaja, Alex W Hewitt, Jamie E Craig, David A Mackey, Janey L Wiggs, Cornelia van Duijn, Michelle K Lupton, Jue-Sheng Ong, Stuart MacGregor, Puya Gharahkhani
发表日期
2023/6/1
期刊
EBioMedicine
卷号
92
出版商
Elsevier
简介
Background
Primary open-angle glaucoma (POAG) is an optic neuropathy characterized by progressive degeneration of the optic nerve that leads to irreversible visual impairment. Multiple epidemiological studies suggest an association between POAG and major neurodegenerative disorders (Alzheimer's disease, amyotrophic lateral sclerosis, frontotemporal dementia, and Parkinson's disease). However, the nature of the overlap between neurodegenerative disorders, brain morphology and glaucoma remains inconclusive.
Method
In this study, we performed a comprehensive assessment of the genetic and causal relationship between POAG and neurodegenerative disorders, leveraging genome-wide association data from studies of magnetic resonance imaging of the brain, POAG, and four major neurodegenerative disorders.
Findings
This study found a genetic overlap and causal relationship between POAG and …
学术搜索中的文章
S Diaz-Torres, W He, J Thorp, S Seddighi, S Mullany… - EBioMedicine, 2023