查看文章

In resource-limited settings, few data are available on virological failure after long-term first-line antiretroviral therapy. This study characterized the genotypic resistance patterns at the time of failure after at least 36 months of a first-line regimen in Mali, West Africa.

Plasma samples from 84 patients who were receiving first-line antiretroviral treatment and with an HIV-1 RNA viral load (VL) >1000 copies/mL were analysed. Genotypic resistance testing was performed and HIV-1 drug resistance was interpreted according to the latest version of the National Agency for HIV and Hepatitis Research algorithm.

At the time of resistance testing, patients had been treated for a median of 60 months (IQR 36–132 months) and had a median CD4 cell count of 292 cells/mm³ (IQR 6–1319 cells/mm³), a median HIV-1 RNA level of 28 266 copies/mL …