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Research dealing on butyrogenic bacteria, ie capable to produce butyric acid, has gained considerable attention in recent years, since butyric acid exerts an extensive influence on host physiology and gut homeostasis in humans by preventing several intestinal metabolic syndromes and their consequential severe degenerations, first of all the colorectal cancer (CRC). In this frame it is noteworthy that CRC-associated microbiota is modified by probiotic administration, which may represent a relative cheap intervention, capable to enrich the abundance of butyrogenic bacteria in the mucosal layer (Hibberd et al., 2017). This Short Chain Fatty Acid (SCFA) is the end-product of the intestinal microbial fermentation of undigested dietary fibres, which is mainly ascribed to members of Firmicutes, such as Lachnospiraceae, Ruminococcaceae and Clostridium spp. Potential butyrogenic capability of Human Intestinal Microbiome (HIM) is currently inferred by ampliconbased sequencing and metagenomics. These approaches target specific key genes of butanoate pathway that encode for the final enzymatic conversion of butyril-CoA to butyric acid via transferases and butyrate kinase (Vital et al., 2014). As for all Lactobacillus sp. that transiently colonize the gut microbiota, Lactobacillus (L.) plantarum is considered both an indirect and direct butyrogenic species, which may certainly acts by favouring butyric acid production of other bacteria or directly producing this SCFA in a strain-dependent manner and in response to specific nutrient requirements. In accordance with the fermentation of fibres occurring in the large intestine, production of butyric acid in L …