作者
Katerina Spyridopoulou, Georgios Aindelis, Evangeli Lampri, Maria Giorgalli, Eleftheria Lamprianidou, Ioannis Kotsianidis, Anastasia Tsingotjidou, Aglaia Pappa, Orestis Kalogirou, Katerina Chlichlia
发表日期
2018/12/15
期刊
Annals of Biomedical Engineering
卷号
46
页码范围
1975-1987
出版商
Springer US
简介
Murine tumor models have played a fundamental role in the development of novel therapeutic interventions and are currently widely used in translational research. Specifically, strategies that aim at reducing inter-animal variability of tumor size in transplantable mouse tumor models are of particular importance. In our approach, we used magnetic nanoparticles to label and manipulate colon cancer cells for the improvement of the standard syngeneic subcutaneous mouse tumor model. Following subcutaneous injection on the scruff of the neck, magnetically-tagged implanted cancer cells were manipulated by applying an external magnetic field towards localized tumor formation. Our data provide evidence that this approach can facilitate the formation of localized tumors of similar shape, reducing thereby the tumor size’s variability. For validating the proof-of-principle, a low-dose of 5-FU was administered in …
学术搜索中的文章
K Spyridopoulou, G Aindelis, E Lampri, M Giorgalli… - Annals of Biomedical Engineering, 2018