作者
Shahzad Shaefi, Samantha K Brenner, Shruti Gupta, Brian P O’Gara, Megan L Krajewski, David M Charytan, Sobaata Chaudhry, Sara H Mirza, Vasil Peev, Mark Anderson, Anip Bansal, Salim S Hayek, Anand Srivastava, Kusum S Mathews, Tanya S Johns, Amanda Leonberg-Yoo, Adam Green, Justin Arunthamakun, Keith M Wille, Tanveer Shaukat, Harkarandeep Singh, Andrew J Admon, Matthew W Semler, Miguel A Hernán, Ariel L Mueller, Wei Wang, David E Leaf
发表日期
2021/2
期刊
Intensive care medicine
卷号
47
页码范围
208-221
出版商
Springer Berlin Heidelberg
简介
Purpose
Limited data are available on venovenous extracorporeal membrane oxygenation (ECMO) in patients with severe hypoxemic respiratory failure from coronavirus disease 2019 (COVID-19).
Methods
We examined the clinical features and outcomes of 190 patients treated with ECMO within 14 days of ICU admission, using data from a multicenter cohort study of 5122 critically ill adults with COVID-19 admitted to 68 hospitals across the United States. To estimate the effect of ECMO on mortality, we emulated a target trial of ECMO receipt versus no ECMO receipt within 7 days of ICU admission among mechanically ventilated patients with severe hypoxemia (PaO2/FiO2 < 100). Patients were followed until hospital discharge, death, or a minimum of 60 days. We adjusted for confounding using a multivariable Cox model …
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S Shaefi, SK Brenner, S Gupta, BP O'Gara… - Intensive care medicine, 2021