作者
Mareike Gierhardt, Oleg Pak, Akylbek Sydykov, Simone Kraut, Julia Schäffer, Claudia Garcia, Christine Veith, Esraa M Zeidan, Monika Brosien, Karin Quanz, Azadeh Esfandiary, Alireza Saraji, Stefan Hadzic, Baktybek Kojonazarov, Jochen Wilhelm, Hossein A Ghofrani, Ralph T Schermuly, Werner Seeger, Friedrich Grimminger, Christiane Herden, Rainer Schulz, Norbert Weissmann, Jacqueline Heger, Natascha Sommer
发表日期
2022/1/1
期刊
Cardiovascular Research
卷号
118
期号
1
页码范围
305-315
出版商
Oxford University Press
简介
Aims
The pulmonary vascular tone and hypoxia-induced alterations of the pulmonary vasculature may be regulated by the mitochondrial membrane permeability transition pore (mPTP) that controls mitochondrial calcium load and apoptosis. We thus investigated, if the mitochondrial proteins p66shc and cyclophilin D (CypD) that regulate mPTP opening affect the pulmonary vascular tone.
Methods and results
Mice deficient for p66shc (p66shc−/−), CypD (CypD−/−), or both proteins (p66shc/CypD−/−) exhibited decreased pulmonary vascular resistance (PVR) compared to wild-type mice determined in isolated lungs and in vivo. In contrast, systemic arterial pressure was only lower in CypD−/− mice. As cardiac function and pulmonary vascular remodelling did not differ between genotypes, we determined alterations of vascular contractility in isolated lungs and calcium handling in …
学术搜索中的文章
M Gierhardt, O Pak, A Sydykov, S Kraut, J Schäffer… - Cardiovascular Research, 2022