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Manganese dioxide (MnO₂)‐based nanoparticles are a promising tumor microenvironment‐responsive nanotheranostic carrier for targeted magnetic resonance imaging (MRI) and for alleviating tumor hypoxia. However, the complexity and potential toxicity of the present common synthesis methods limit their clinical application. Herein, multifunctional hyaluronic acid‐MnO₂ nanoparticles (HA‐MnO₂ NPs) are synthesized in a simple way by directly mixing sodium permanganate with HA aqueous solutions, which serve as both a reducing agent and a surface‐coating material. The obtained HA‐MnO₂ NPs show an improved water‐dispersibility, fine colloidal stability, low toxicity, and responsiveness to the tumor microenvironment (high H₂O₂ and high glutathione, low pH). After intravenous injection, HA‐MnO₂ NPs exhibit a high imaging sensitivity for detecting rat intracranial glioma with MRI for a prolonged period of …