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Most recently in Nature Journal, Ke et al. thoroughly investigate the SARS-CoV-2 spike in situ by using cryo-electron microscopy (Cryo-EM) to reveal its different conformations, orientations, and distribution over the virion particles. 1 The cornerstone of any viral infection is the recognition of the viral element, usually a glycoprotein, to the host cell receptors. Knowledge of the behavior of viral glycoprotein is crucial for understanding the mode of infection and designing a vaccine against viruses. The spike glycoprotein is the critical viral element that is responsible for host cell recognition, attachment, and entry for the human coronaviruses. The trimeric spikes are the transmembrane protein that undergoes dramatic structural rearrangements for binding to its host cell receptor, the angiotensin-converting enzyme 2 (ACE2), that mediate subsequent membrane fusion and virion entry. 2 The novel human coronavirus strain …