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New coumarin based Schiff base (7MIZ) was synthesized and characterized by various spectral techniques and the true nature was established by X-ray single crystal studies. The probe (7MIZ) acted as fluorescent sensor for detection of Al³⁺ ion among different metal ions (chloride salts) with high selectively. There was a drastic enhancement in the emission intensity at 482 nm showed fluorescence turn ^‘ON^’ behavior of the probe when it interacted with Al³⁺ ion which may be due to CHEF (chelation enhanced fluorescence) effect that inhibited the PET (photo-induced electron transfer) mechanism. Further, Job's plot, binding constant value, LOD value, DFT studies established the interaction between probe (7MIZ) andAl³⁺ ion and MTT assay studies were carried out for the probe (7MIZ) and Al³⁺ ion in Breast cancer cell line (MDA-MB-231).