作者
Francesca Graziani, Pio Cialdella, Giovanna Liuzzo, Eloisa Basile, Salvatore Brugaletta, Daniela Pedicino, Laura Leccesi, Caterina Guidone, Amerigo Iaconelli, Geltrude Mingrone, Luigi Marzio Biasucci, Filippo Crea
发表日期
2011/8/1
期刊
European journal of internal medicine
卷号
22
期号
4
页码范围
418-423
出版商
Elsevier
简介
BACKGROUND
Both inflammation and immunity are involved in the development and progression of atherosclerosis. Obesity is considered a major modifiable cardiovascular risk factor, however, the correlation between increasing degrees of obesity and cardiovascular risk is not clear yet. Aim of our study was to investigate how different degrees of obesity are associated with inflammation and immune system responses.
METHODS
One-hundred healthy individuals were divided into 3 groups according to body mass index (BMI): 22 overweight (OW), 26 obese (O) and 52 morbidly obese (MO). High-sensitivity C-Reactive Protein (hs-CRP, immunonephelometry), leptin (radio-immunoassay) and CD4+CD28nullT-lymphocytes (flow-cytometry), a particular subset of T-lymphocytes with pro-atherogenic and plaque-destabilizing properties, were assessed.
RESULTS
hs-CRP levels were significantly higher in O vs OW (p …
学术搜索中的文章
F Graziani, P Cialdella, G Liuzzo, E Basile, S Brugaletta… - European journal of internal medicine, 2011