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The combination of Pt nanoparticles and graphene was more effective in enhancing biosensing than either nanomaterial alone according to previous reports. Based on the structural similarities between water soluble graphene oxide (GrO_x) and graphene, we report the fabrication of an aqueous media based GrO_x/Pt-black nanocomposite for biosensing enhancement. In this approach GrO_x acted as a nanoscale molecular template for the electrodeposition of Pt-black, an amorphously nanopatterned isoform of platinum metal. Scanning electron microscopy (SEM) images and energy-dispersive X-ray spectroscopy (EDS) showed that Pt-black was growing along GrO_x. The effective surface area and electrocatalytic activity towards H₂O₂ oxidation of GrO_x/Pt-black microelectrodes were significantly higher than for Pt-black microelectrodes. When used to prepare a bio-nanocomposite based on protein functionalization …