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Delirium is a distressing neurocognitive disorder recently linked to sleep disturbances. However, the longitudinal relationship between sleep and delirium remains unclear. This study assessed the associations of poor sleep burden, and its trajectory, with delirium risk during hospitalization.

About 321 818 participants from the UK Biobank (mean age 58 ± 8 years [SD]; range 37–74 years) reported (2006–2010) sleep traits (sleep duration, excessive daytime sleepiness, insomnia-type complaints, napping, and chronotype—a closely related circadian measure for sleep timing), aggregated into a sleep burden score (0–9). New-onset delirium (n = 4 775) was obtained from hospitalization records during a 12-year median follow-up. About 42 291 (mean age 64 ± 8 years; range 44–83 years) had repeat sleep assessment on average 8 years after their first …