作者
Till Keller, Tanja Zeller, Dirk Peetz, Stergios Tzikas, Alexander Roth, Ewa Czyz, Christoph Bickel, Stephan Baldus, Ascan Warnholtz, Meike Fröhlich, Christoph R Sinning, Medea S Eleftheriadis, Philipp S Wild, Renate B Schnabel, Edith Lubos, Nicole Jachmann, Sabine Genth-Zotz, Felix Post, Viviane Nicaud, Laurence Tiret, Karl J Lackner, Thomas F Münzel, Stefan Blankenberg
发表日期
2009/8/27
期刊
New England Journal of Medicine
卷号
361
期号
9
页码范围
868-877
出版商
Massachusetts Medical Society
简介
Background
Cardiac troponin testing is central to the diagnosis of acute myocardial infarction. We evaluated a sensitive troponin I assay for the early diagnosis and risk stratification of myocardial infarction.
Methods
In a multicenter study, we determined levels of troponin I as assessed by a sensitive assay, troponin T, and traditional myocardial necrosis markers in 1818 consecutive patients with suspected acute myocardial infarction, on admission and 3 hours and 6 hours after admission.
Results
For samples obtained on admission, the diagnostic accuracy was highest with the sensitive troponin I assay (area under the receiver-operating-characteristic curve [AUC], 0.96), as compared with the troponin T assay (AUC, 0.85) and traditional myocardial necrosis markers. With the use of the sensitive troponin I assay (cutoff value, 0.04 ng per milliliter) on admission, the clinical sensitivity was 90.7%, and the specificity …
引用总数
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T Keller, T Zeller, D Peetz, S Tzikas, A Roth, E Czyz… - New England Journal of Medicine, 2009