作者
Ashlan J Kunz Coyne, Amer El Ghali, Kristen Lucas, Paige Witucki, Nicholas Rebold, Dana J Holger, Michael P Veve, Michael J Rybak
发表日期
2023/3/1
期刊
Open Forum Infectious Diseases
卷号
10
期号
3
页码范围
ofad034
出版商
Oxford University Press
简介
Background
Limited data suggest that serious infections caused by Enterobacterales with a moderate to high risk of clinically significant AmpC production can be successfully treated with cefepime if the cefepime minimum inhibitory concentration (MIC) is ≤2 µg/mL. However, isolates with a cefepime-susceptible dose-dependent (SDD) MIC of 4–8 µg/mL should receive a carbapenem due to target attainment and extended-spectrum β-lactamase (ESBL) concerns.
Methods
This was a retrospective cohort study of hospitalized patients with E. cloacae, K. aerogenes, or C. freundii bacteremia from January 2015 to March 2022 receiving high-dose cefepime or a carbapenem. Cox regression models were used with incorporation of inverse probability of treatment weighting and time-varying covariates.
Results
Of the 315 patients included, 169 received cefepime …
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