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The adverse effects of spraying pesticides to the ecosystem are being widely studied. While the effects of their oral and topical exposure have been reported, especially on carbohydrate metabolism, the effects of inhalational exposure have not been reported. Hence, this study was undertaken to investigate the effects of malathion, a commonly used pesticide, on blood glucose and antioxidant status in rats. In acute study, 8 groups of 6 animals each were exposed to 50% malathion for 5 min. Blood glucose level was estimated for all the rats before exposure and at 5, 10, 20, 30, 60 120, 180 and 240 min after exposure for groups G to 8, respectively. Blood glucose increased from the basal level of 88 mg dLr1, reached 131 mgdLr1 in 60 min and attained basal level at 240 min. In sub chronic study, there were two groxips of 6 animals each control and test. Test group was exposed to malathion vapours for 5 min every …