作者
Sarah P Garnett, Louise A Baur, Manny Noakes, Katharine Steinbeck, Helen J Woodhead, Susie Burrell, Kerryn Chisholm, Carolyn R Broderick, Robert Parker, Sukanya De, Shubha Shrinivasan, Lori Hopley, Gilly Hendrie, Geoffrey R Ambler, Michael R Kohn, Chris T Cowell
发表日期
2010/12
期刊
BMC Public Health
卷号
10
页码范围
1-10
出版商
BioMed Central
简介
Background
Concomitant with the rise in childhood obesity there has been a significant increase in the number of adolescents with clinical features of insulin resistance and prediabetes. Clinical insulin resistance and prediabetes are likely to progress to type 2 diabetes and early atherosclerosis if not targeted for early intervention. There are no efficacy trials of lifestyle intervention in this group to inform clinical practice. The primary aim of this randomised control trial (RCT) is to determine the efficacy and effectiveness of two different structured lifestyle interventions differing in diet composition on insulin sensitivity, in adolescents with clinical insulin resistance and/or prediabetes treated with metformin.
Methods/design
This study protocol describes the design of an ongoing RCT. We are recruiting 108 (54 each treatment arm) 10 to 17 year olds with clinical …
学术搜索中的文章
SP Garnett, LA Baur, M Noakes, K Steinbeck… - BMC Public Health, 2010