作者
Sarah P Garnett, Megan Gow, Mandy Ho, Louise A Baur, Manny Noakes, Helen J Woodhead, Carolyn R Broderick, Susie Burrell, Kerryn Chisholm, Jocelyn Halim, Sukanya De, Katherine Steinbeck, Shubha Srinivasan, Geoffrey R Ambler, Michael R Kohn, Chris T Cowell
发表日期
2013/5/1
期刊
The Journal of Clinical Endocrinology & Metabolism
卷号
98
期号
5
页码范围
2116-2125
出版商
Oxford University Press
简介
Context
Prediabetes and clinical insulin resistance in adolescents are rapidly emerging clinical problems with serious health outcomes.
Objective
The objective of this study was to determine the efficacy of 2 structured lifestyle interventions, both differing in diet macronutrient composition, on insulin sensitivity.
Design
This study was a randomized controlled trial, known as Researching Effective Strategies to Improve Insulin Sensitivity in Children and Teenagers, in 2 hospitals in Sydney, Australia.
Participants
Participants included overweight or obese 10- to 17-year-olds with either prediabetes and/or clinical features of insulin resistance.
Intervention
At baseline adolescents were prescribed metformin and randomized to a structured diet, which was either high carbohydrate or moderate carbohydrate with increased protein …
学术搜索中的文章
SP Garnett, M Gow, M Ho, LA Baur, M Noakes… - The Journal of Clinical Endocrinology & Metabolism, 2013