查看文章

The antidepressant-like effect of the ethanolic extract obtained from barks of Tabebuia avellanedae, a plant widely employed in folk medicine, was investigated in two predictive models of depression: forced swimming test (FST) and tail suspension test (TST) in mice. Additionally, the mechanisms involved in this antidepressant-like action and the effects of the association of the extract with the antidepressants fluoxetine, desipramine and bupropion in the TST were investigated. The extract from T. avellanedae produced an antidepressant-like effect, in the FST (100mg/kg, p.o.) and in the TST (10–300mg/kg, p.o.), without accompanying changes in ambulation when assessed in the open-field test. The anti-immobility effect of the extract (30mg/kg, p.o.) in the TST was prevented by pre-treatment of mice with ketanserin (5mg/kg, i.p., a preferential 5-HT_2A receptor antagonist), prazosin (1mg/kg, i.p., an α₁-adrenoceptor …