作者
Hang Zhou, Christopher T Rentsch, Zhongshan Cheng, Rachel L Kember, Yaira Z Nunez, Richard M Sherva, Janet P Tate, Cecilia Dao, Ke Xu, Renato Polimanti, Lindsay A Farrer, Amy C Justice, Henry R Kranzler, Joel Gelernter
发表日期
2020/10/1
期刊
JAMA psychiatry
卷号
77
期号
10
页码范围
1072-1080
出版商
American Medical Association
简介
Importance
With the current opioid crisis, it is important to improve understanding of the biological mechanisms of opioid use disorder (OUD).
Objectives
To detect genetic risk variants for OUD and determine genetic correlations and causal association with OUD and other traits.
Design, Setting, and Participants
A genome-wide association study of electronic health record–defined OUD in the Million Veteran Program sample was conducted, comprising 8529 affected European American individuals and 71 200 opioid-exposed European American controls (defined by electronic health record trajectory analysis) and 4032 affected African American individuals and 26 029 opioid-exposed African American controls. Participants were enrolled from January 10, 2011, to May 21, 2018, with electronic health record data for OUD diagnosis from October 1, 1999, to February 7, 2018. Million Veteran Program results and …
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H Zhou, CT Rentsch, Z Cheng, RL Kember, YZ Nunez… - JAMA psychiatry, 2020