作者
Oliver Patschan, Gottfrid Sjödahl, Gunilla Chebil, Kristina Lövgren, Martin Lauss, Sigurdur Gudjonsson, Petter Kollberg, Pontus Eriksson, Mattias Aine, Wiking Månsson, Mårten Fernö, Fredrik Liedberg, Mattias Höglund
发表日期
2015/11/1
期刊
European urology
卷号
68
期号
5
页码范围
824-832
出版商
Elsevier
简介
Background
One third of patients with stage T1 urothelial carcinoma (UC) progress to muscle-invasive disease requiring radical surgery. Thus, reliable tools are needed for risk stratification of stage T1 UC.
Objective
To investigate the extent to which stratification of stage T1 tumours into previously described molecular pathologic UC subtypes can provide improved information on tumour progression.
Design, setting, and participants
A population-based cohort of 167 primary stage T1 UCs was characterised by immunohistochemistry and classified into the molecular subtypes urobasal (Uro, 32%), genomically unstable (GU, 58%), and squamous-cell-carcinoma–like (SCCL, 10%).
Outcome measurements and statistical analysis
Progression-free survival using univariate and multivariate models.
Results and limitations
Subtype classification was validated using nine additional markers with known subtype-specific …
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O Patschan, G Sjödahl, G Chebil, K Lövgren, M Lauss… - European urology, 2015