作者
Gottfrid Sjödahl, Kristina Lövgren, Martin Lauss, Gunilla Chebil, Oliver Patschan, Sigurdur Gudjonsson, Wiking Månsson, Mårten Fernö, Karin Leandersson, David Lindgren, Fredrik Liedberg, Mattias Höglund
发表日期
2014/8/1
期刊
Urologic Oncology: Seminars and Original Investigations
卷号
32
期号
6
页码范围
791-797
出版商
Elsevier
简介
Objectives
Urothelial carcinoma (UC) aggressiveness is determined by tumor inherent molecular characteristics, such as molecular subtypes, as well as by host reactions directed toward the tumor. Cell types responsible for the host׳s response include tumor-infiltrating lymphocytes (TILs) and tumor-associated macrophages (TAMs). The aim of the present investigation was to explore the immunological response in relation to UC molecular subtypes and to evaluate the prognostic effect of TIL and TAM counts in tissue sections from muscle-invasive (MI) tumors.
Methods and materials
Tissue microarrays with 296 tumors spanning all pathological stages and grades were analyzed with antibodies for CD3, CD8, FOXP3, CD68, and CD163. Cases were classified into the following molecular subtypes: urobasal, genomically unstable, and squamous cell carcinoma–like using a combination of immunohistochemistry and …
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G Sjödahl, K Lövgren, M Lauss, G Chebil, O Patschan… - Urologic Oncology: Seminars and Original …, 2014