作者
Ida Johansson, Cecilia Nilsson, Pontus Berglund, Martin Lauss, Markus Ringnér, Håkan Olsson, Lena Luts, Edith Sim, Sten Thorstensson, Marie-Louise Fjällskog, Ingrid Hedenfalk
发表日期
2012/2
期刊
Breast Cancer Research
卷号
14
页码范围
1-15
出版商
BioMed Central
简介
Introduction
Male breast cancer (MBC) is a rare and inadequately characterized disease. The aim of the present study was to characterize MBC tumors transcriptionally, to classify them into comprehensive subgroups, and to compare them with female breast cancer (FBC).
Methods
A total of 66 clinicopathologically well-annotated fresh frozen MBC tumors were analyzed using Illumina Human HT-12 bead arrays, and a tissue microarray with 220 MBC tumors was constructed for validation using immunohistochemistry. Two external gene expression datasets were used for comparison purposes: 37 MBCs and 359 FBCs.
Results
Using an unsupervised approach, we classified the MBC tumors into two subgroups, luminal M1 and luminal M2, respectively, with differences in tumor biological features and outcome, and which …
学术搜索中的文章
I Johansson, C Nilsson, P Berglund, M Lauss… - Breast Cancer Research, 2012