作者
JohnD Clemens, JeffreyR Harris, Moslem Rahman Khan, BradfordA Kay, MD Yunus, Ann-Mari Svennerholm, DavidA Sack, J Chakraborty, BonitaF Stanton, MU Khan, William Atkinson, Jan Holmgren
发表日期
1986/7/19
期刊
The Lancet
卷号
328
期号
8499
页码范围
124-127
出版商
Elsevier
简介
The protective efficacy of oral B subunit killed whole-cell (BS-WC) and killed whole-cell (WC) cholera vaccines was assessed in 63 498 Bangladeshi children aged 2-15 years and women aged over 15 years. Each received three doses of BS-WC, WC, or placebo in a randomised, double-blinded fashion. Surveillance for cases seeking medical care up to six months after the third dose revealed 26 cases of confirmed cholera in the placebo group, 4 cases in the BS-WC group (protective efficacy 85%; p<0·0001), and 11 cases in the WC group (protective efficacy 58%; p<0·01). For each vaccine protective efficacy was consistent in different age-groups (2-10 years versus >10 years) and for different severities of cholera.
引用总数
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