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Studies in animals and humans suggest a role for peptide YY (PYY_3–36) in regulating satiety. The physiologic role of PYY_3–36, however, has not been investigated in detail.

The present study was designed to examine PYY release in response to 2 meals differing in their calorie content and to relate the plasma levels to those obtained after exogenous infusion. In a second step, the effect of graded intravenous doses (0, 0.2, 0.4, and 0.8 pmol·kg⁻¹·min⁻¹) of synthetic human PYY_3–36 on food intake was investigated in healthy male volunteers in a double-blind, placebo-controlled fashion.

Plasma PYY concentrations increased in response to food intake reflecting the size of the calorie load. Graded PYY_3–36 infusions resulted in a dose-dependent reduction in food intake (maximal inhibition, 35%; P < .001 vs control) and a similar reduction in calorie intake (32%; P < .001). Fluid …