作者
R Smieskova, Paolo Fusar-Poli, Paul Allen, K Bendfeldt, RD Stieglitz, J Drewe, EW Radue, PK McGuire, A Riecher-Rössler, SJ Borgwardt
发表日期
2010/7/1
来源
Neuroscience & Biobehavioral Reviews
卷号
34
期号
8
页码范围
1207-1222
出版商
Pergamon
简介
OBJECTIVES
In early stage psychosis research the identification of neurobiological correlates of vulnerability to schizophrenia is an important hurdle.
METHODS
We systematically reviewed the neuroimaging publications on high-risk subjects with subsequent transition to psychosis (HR-T) and conducted a meta-analysis calculating the effect size Cohen's d.
RESULTS
Out of 30 identified studies 25 met the inclusion criteria. Structural (s)MRI studies showed small to medium effect sizes of decreased prefrontal, cingulate, insular and cerebellar gray matter volume in HR-T compared to high-risk subjects without transition (HR-NT). Meta-analysis revealed relatively larger whole brain volumes in HR-T compared to HR-NT subjects (mean Cohen's d 0.36, 95% CI 0.27–0. 46). Compared to HR-NT, HR-T subjects showed in functional imaging studies reduced brain activation in prefrontal cortex, reduced neuronal density …
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