作者
Matthew T Neal, Michael D Chan, John T Lucas Jr, Amritraj Loganathan, Christine Dillingham, Edward Pan, John H Stewart IV, J Daniel Bourland, Edward G Shaw, Stephen B Tatter, Thomas L Ellis
发表日期
2014/12/1
来源
World neurosurgery
卷号
82
期号
6
页码范围
1250-1255
出版商
Elsevier
简介
Objective
This study sought to assess clinical outcomes in patients receiving gamma knife radiosurgery (GK) for treatment of brain metastases from melanoma and evaluate for potential predictive factors.
Methods
We reviewed 188 GK procedures in 129 consecutive patients that were treated for brain metastases from melanoma. The population consisted of 84 males and 45 females with a median age of 57 years. Fifty-five patients (43%) had a single metastasis. Seventy-one patients (55%) received chemotherapy, 58 patients (45%) received biologic agents, and 36 patients (28%) received prior whole brain radiation therapy (WBRT). The median marginal dose was 18.8 Gy (range 12 to 24 Gy).
Results
Actuarial survival was 52%, 26%, and 13% at 6, 12, and 24 months, respectively. The median survival time was 6.7 months. Local tumor control was 95%, 81% 53% at 6, 12, and 24 months, respectively. The median time …
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MT Neal, MD Chan, JT Lucas Jr, A Loganathan… - World neurosurgery, 2014
