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To analyze the role of serum LH and of E₂ secretion on IVF-ET outcome in patients stimulated with FSH.

Using data from three studies, we analyzed ovarian response to FSH and IVF-ET outcome from two standpoints: [1] serum LH and [2] serum E₂ on the day of hCG administration divided by the number of retrieved oocytes.

Twenty-six academic and private clinical centers. Patient(s): Three hundred twenty-three ovulatory patients eligible for IVF-ET. Intervention(s): Patients were treated with a GnRH agonist and FSH and underwent IVF-ET. Main Outcome Measure(s): Follicular development, embryos, and pregnancy rate (PR). Result(s): Serum LH levels did not correlate significantly with number of oocytes retrieved, E₂-oocyte ratio, fertilization rate, or PR. Five patient subpopulations were identified on the basis of E₂-oocyte ratios: 0 to 70 (A), 70 to 140 (B), 140 to 210 (C), 210 to 280 (D), and …