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Methods: A total of 101 patients who received the renal transplantation in Seoul national university hospital were prospectively enrolled in this study. The coefficient of variation (CV) which represents the ratio of the standard deviation (SD) to the mean, was used for the quantification of the IPV. We divided the cohorts into High IPV group and Low IPV group based on the several criteria using mean and subdivided SD of CV. Genetic analysis was conducted to determine which genes were associated with tacrolimus IPV.

Results: When we divided the cohorts as criteria of the mean+ 0.25 SD, there are more biopsy-proven tacrolimus nephrotoxicity in High IPV group than in Low IPV group (64.3% vs 35.7%, p= 0.012). Follow up periods was not different between two groups (3.34±0.59 years and 3.23±0.66 years, respectively, p= 0.514). There were no differences in mean tacrolimus concentration (6.82±1.23 mg/dL vs 7 …