查看文章

Synthetic nanomaterials have many unique chemical and physical properties, mainly due to their high specific surface area and quantum confinement effect. Specifically, titanium dioxide (TiO₂) nanomaterial has high stability, anticorrosive, and photocatalytic properties. However, there are concerns over adverse biological effects resulting from bioeffects. This study was to investigate adverse effects associated with acute ingestion of TiO₂ nanofiber (TDNF). TDNF was fabricated via electrospinning method, followed by dissolution in water. Six‐ to seven‐week‐old male Sprague Dawley rats were exposed to a total of 0, 40, and 60 ppm of TDNF for 2 weeks via oral gavage. Serum total protein and weight gain during the course of this study displayed marginal concentration‐dependent alterations. These findings were followed by a global gene expression analysis to identify which transcripts might be responsive to …