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The mutagen 2-aminoanthracene (2-AA) is an aromatic amine or arylamine, which belongs to a class of polycyclic aromatic hydrocarbons. 2-AA is used in the manufacturing of a wide variety of chemicals, drugs, dyes and polymers. Non-occupational sources include tobacco smoking and cooked foods. The goal of this study is to evaluate pancreatic gene expression patterns in Fischer-344 (F-344) male rats exposed to 2-AA. As a first step the effects of 2-aminoanthracene exposure on the pancreas with particular interest in genes that relate to insulin and insulin metabolism. To achieve this goal, twenty-four post-weaning, 3-4 week old F-344 male rats were exposed to 0 mg kg-1-diet (control), 50 mg kg^-1-diet (low dose), 75 mg kg^-1-diet (medium dose) and 100 mg kg^-1-diet (high dose) 2-AA for 14 and 28 days followed by analysis of the pancreas for broad gene expression changes. Results obtained from our study …