作者
Brijesh V Patel, Deepa J Arachchillage, Carole A Ridge, Paolo Bianchi, James F Doyle, Benjamin Garfield, Stephane Ledot, Cliff Morgan, Maurizio Passariello, Susanna Price, Suveer Singh, Louit Thakuria, Sarah Trenfield, Richard Trimlett, Christine Weaver, S John Wort, Tina Xu, Simon PG Padley, Anand Devaraj, Sujal R Desai
发表日期
2020/9/1
期刊
American journal of respiratory and critical care medicine
卷号
202
期号
5
页码范围
690-699
出版商
American Thoracic Society
简介
Rationale: Clinical and epidemiologic data in coronavirus disease (COVID-19) have accrued rapidly since the outbreak, but few address the underlying pathophysiology.
Objectives: To ascertain the physiologic, hematologic, and imaging basis of lung injury in severe COVID-19 pneumonia.
Methods: Clinical, physiologic, and laboratory data were collated. Radiologic (computed tomography (CT) pulmonary angiography [n = 39] and dual-energy CT [DECT, n = 20]) studies were evaluated: observers quantified CT patterns (including the extent of abnormal lung and the presence and extent of dilated peripheral vessels) and perfusion defects on DECT. Coagulation status was assessed using thromboelastography.
Measurements and Results: In 39 consecutive patients (male:female, 32:7; mean age, 53 ± 10 yr [range, 29–79 yr]; Black and minority ethnic, n = 25 [64%]), there was a significant vascular perfusion …
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BV Patel, DJ Arachchillage, CA Ridge, P Bianchi… - American journal of respiratory and critical care …, 2020