作者
Dustin T Yates, Leticia E Camacho, Amy C Kelly, Leah V Steyn, Melissa A Davis, Andrew T Antolic, Miranda J Anderson, Ravi Goyal, Ronald E Allen, Klearchos K Papas, William W Hay Jr, Sean W Limesand
发表日期
2019/12
期刊
The Journal of physiology
卷号
597
期号
24
页码范围
5835-5858
简介
Key points
- Previous studies in fetuses with intrauterine growth restriction (IUGR) have shown that adrenergic dysregulation was associated with low insulin concentrations and greater insulin sensitivity.
- Although whole‐body glucose clearance is normal, 1‐month‐old lambs with IUGR at birth have higher rates of hindlimb glucose uptake, which may compensate for myocyte deficiencies in glucose oxidation.
- Impaired glucose‐stimulated insulin secretion in IUGR lambs is due to lower intra‐islet insulin availability and not from glucose sensing.
- We investigated adrenergic receptor (ADR) β2 desensitization by administering oral ADRβ modifiers for the first month after birth to activate ADRβ2 and antagonize ADRβ1/3. In IUGR lambs ADRβ2 activation increased whole‐body glucose utilization rates and insulin sensitivity but had no effect on isolated islet or myocyte deficiencies.
- IUGR establishes risk for developing …
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DT Yates, LE Camacho, AC Kelly, LV Steyn, MA Davis… - The Journal of physiology, 2019
