作者
Carlos AR Veo, Sarhan S Saad, José Humberto TG Fregnani, Cristovam Scapulatempo-Neto, Audrey Tieko Tsunoda, Júlio César Possati Resende, Adriana Tarlá Lorenzi, Allini Mafra, Claudia Cinti, Ismael Dale Cotrim, Luciana Albina Reis Rosa, Cristina Mendes de Oliveira, Toni Ricardo Martins, Cristiane Centrone, José Eduardo Levi, Adhemar Longatto-Filho
发表日期
2015/7
期刊
Tumor Biology
卷号
36
页码范围
5399-5405
出版商
Springer Netherlands
简介
High-risk human papillomavirus (hrHPV) is an essential cause of cervical carcinoma and is also strongly related to anal cancer development. The hrHPV E6 oncoprotein plays a major role in carcinogenesis. We aimed to evaluate the frequency of hrHPV DNA and E6 oncoprotein in the anuses of women with cervical carcinoma. We analyzed 117 women with cervical cancer and 103 controls for hrHPV and the E6 oncogene. Positive test results for a cervical carcinoma included 66.7 % with hrHPV-16 and 7.7 % with hrHPV-18. One case tested positive for both HPV variants (0.9 %). The samples from the anal canal were positive for HPV-16 in 59.8 % of the cases. Simultaneous presence of HPV in the cervix and anal canal was found in 53.8 % of the cases. Regarding expression of E6 RNA, positivity for HPV-16 in the anal canal was found in 21.2 % of the cases, positivity for HPV-16 in the cervix was found in …
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CAR Veo, SS Saad, JHTG Fregnani… - Tumor Biology, 2015