作者
Symen Ligthart, Ahmad Vaez, Urmo Võsa, Maria G Stathopoulou, Paul S De Vries, Bram P Prins, Peter J Van der Most, Toshiko Tanaka, Elnaz Naderi, Lynda M Rose, Ying Wu, Robert Karlsson, Maja Barbalic, Honghuang Lin, René Pool, Gu Zhu, Aurélien Macé, Carlo Sidore, Stella Trompet, Massimo Mangino, Maria Sabater-Lleal, John P Kemp, Ali Abbasi, Tim Kacprowski, Niek Verweij, Albert V Smith, Tao Huang, Carola Marzi, Mary F Feitosa, Kurt K Lohman, Marcus E Kleber, Yuri Milaneschi, Christian Mueller, Mahmudul Huq, Efthymia Vlachopoulou, Leo-Pekka Lyytikäinen, Christopher Oldmeadow, Joris Deelen, Markus Perola, Jing Hua Zhao, Bjarke Feenstra, Behrooz Z Alizadeh, H Marike Boezen, Lude Franke, Pim van der Harst, Gerjan Navis, Marianne Rots, Harold Snieder, Morris Swertz, Bruce HR Wolffenbuttel, Cisca Wijmenga, Marzyeh Amini, Emelia Benjamin, Daniel I Chasman, Abbas Dehghan, Tarunveer Singh Ahluwalia, James Meigs, Russell Tracy, Josh Bis, Gudny Eiriksdottir, Nathan Pankratz, Myron Gross, Alex Rainer, James G Wilson, Bruce M Psaty, Josee Dupuis, Bram Prins, Urmo Vaso, Maria Stathopoulou, Terho Lehtimaki, Wolfgang Koenig, Yalda Jamshidi, Sophie Siest, Andre G Uitterlinden, Mohammadreza Abdollahi, Renate Schnabel, Ursula M Schick, Ilja M Nolte, Aldi Kraja, Yi-Hsiang Hsu, Daniel S Tylee, Alyson Zwicker, Rudolf Uher, George Davey-Smith, Alanna C Morrison, Andrew Hicks, Cornelia M van Duijn, Cavin Ward-Caviness, Eric Boerwinkle, J Rotter, Ken Rice, Leslie Lange, Eco de Geus, Andrew P Morris, Kari Matti Makela, David Stacey, Johan Eriksson, Tim M Frayling, Eline P Slagboom, Jari Lahti, Katharina E Schraut, Myriam Fornage, Bhoom Suktitipat, Wei-Min Chen, Xiaohui Li, Teresa Nutile, Giovanni Malerba, Jian’an Luan, Tom Bak, Nicholas Schork, M Fabiola Del Greco, Elisabeth Thiering, Anubha Mahajan, Riccardo E Marioni, Evelin Mihailov, Joel Eriksson, Ayse Bilge Ozel, Weihua Zhang, Maria Nethander, Yu-Ching Cheng, Stella Aslibekyan, Wei Ang, Ilaria Gandin, Loïc Yengo, Laura Portas, Charles Kooperberg, Edith Hofer, Kumar B Rajan, Claudia Schurmann, Wouter den Hollander, Tarunveer S Ahluwalia, Jing Zhao, Harmen HM Draisma, Ian Ford, Nicholas Timpson, Alexander Teumer, Hongyan Huang, Simone Wahl, YongMei Liu, Jie Huang, Hae-Won Uh, Frank Geller, Peter K Joshi, Lisa R Yanek, Elisabetta Trabetti, Benjamin Lehne, Diego Vozzi, Marie Verbanck, Ginevra Biino, Yasaman Saba
发表日期
2018/11/1
期刊
The American Journal of Human Genetics
卷号
103
期号
5
页码范围
691-706
出版商
Elsevier
简介
C-reactive protein (CRP) is a sensitive biomarker of chronic low-grade inflammation and is associated with multiple complex diseases. The genetic determinants of chronic inflammation remain largely unknown, and the causal role of CRP in several clinical outcomes is debated. We performed two genome-wide association studies (GWASs), on HapMap and 1000 Genomes imputed data, of circulating amounts of CRP by using data from 88 studies comprising 204,402 European individuals. Additionally, we performed in silico functional analyses and Mendelian randomization analyses with several clinical outcomes. The GWAS meta-analyses of CRP revealed 58 distinct genetic loci (p < 5 × 10−8). After adjustment for body mass index in the regression analysis, the associations at all except three loci remained. The lead variants at the distinct loci explained up to 7.0% of the variance in circulating amounts of CRP. We …
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S Ligthart, A Vaez, U Võsa, MG Stathopoulou… - The American Journal of Human Genetics, 2018