作者
Cesar Garriga, Maria T Sánchez‐Santos, Andrew Judge, Deborah Hart, Tim Spector, Cyrus Cooper, Nigel K Arden
发表日期
2020/1
期刊
Arthritis care & research
卷号
72
期号
1
页码范围
88-97
简介
Objective
To develop and internally validate risk models and a clinical risk score tool to predict incident radiographic knee osteoarthritis (RKOA) in middle‐aged women.
Methods
We analyzed 649 women in the Chingford 1,000 Women study. The outcome was incident RKOA, defined as Kellgren/Lawrence grade 0–1 at baseline and ≥2 at year 5. We estimated predictors’ effects on the outcome using logistic regression models. Two models were generated. The clinical model considered patient characteristics, medication, biomarkers, and knee symptoms. The radiographic model considered the same factors, plus radiographic factors (e.g., angle between the acetabular roof and the ilium's vertical cortex [hip α‐angle]). The models were internally validated. Model performance was assessed using calibration and discrimination (area under the receiver characteristic curve [AUC]).
Results
The clinical model …
学术搜索中的文章
C Garriga, MT Sánchez‐Santos, A Judge, D Hart… - Arthritis care & research, 2020