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Frequent alcohol consumption leads to development of alcoholic liver steatosis. Onset of steatosis is caused by alcohol metabolite ‘acetaldehyde’ causing intracellular accumulation of lipid bodies due to abnormal metabolism. Livogrit is a tri-herbal Ayurveda formulation prepared using Boerhavia diffusa L., Phyllanthus niruri L., and Solanum nigrum L. plant extracts. The formulation has earlier proven effective against carbon tetrachloride-induced toxicity and non-alcoholic fatty acid induced liver steatosis.

In present study, we evaluated efficacy of Livogrit in ameliorating ‘acetaldehyde’ induced steatosis and assessed its mode of action.

HepG2 cells were exposed to varying concentrations of acetaldehyde and assessed for lipid body accumulation and cytosafety. An inhibition concentration of 50% for acetaldehyde was observed at 71.42 mM in HepG2 cells. 1 mM acetaldehyde was …