查看文章

Type 2 diabetes mellitus (T2DM) is characterized by the inability of the pancreatic β-cells to secrete enough insulin to meet the demands of the body. Therefore, research of potential therapeutic approaches to treat T2DM has focused on increasing insulin output from β-cells or improving systemic sensitivity to circulating insulin. In this study, we examined the role of the A₁ receptor in glucose homeostasis with the use of A₁ receptor knockout mice (A₁R^−/−). A₁R^−/− mice exhibited superior glucose tolerance compared with wild-type controls. However, glucose-stimulated insulin release, insulin sensitivity, weight gain, and food intake were comparable between the two genotypes. Following a glucose challenge, plasma glucagon levels in wild-type controls decreased, but this was not observed in A₁R^−/− mice. In addition, pancreas perfusion with oscillatory glucose levels of 10-min intervals produced a regular pattern of …