作者
Y Lytvyn, M Škrtić, GK Yang, V Lai, JW Scholey, PM Yip, BA Perkins, DZI Cherney
发表日期
2016/8
期刊
Diabetic Medicine
卷号
33
期号
8
页码范围
1102-1111
简介
Aims
Increased plasma uric acid (PUA) levels are associated with impaired renal function in patients with Type 1 diabetes, but the mechanisms are not well understood. Our aim was to evaluate whether higher PUA levels are associated with increased afferent arteriolar resistance in patients with Type 1 diabetes vs. healthy controls, thereby influencing renal function.
Methods
PUA, GFR (inulin) and effective renal plasma flow (ERPF; para‐aminohippurate) were measured in 70 otherwise healthy patients with Type 1 diabetes and 60 healthy controls. Gomez's equations were used to estimate afferent (RA) and efferent (RE) arteriolar resistances, glomerular hydrostatic pressure (PGLO) and filtration pressure (ΔPF). The relationships between PUA and glomerular haemodynamic parameters were evaluated by univariable linear regression correlation coefficients.
Results
In patients with Type 1 diabetes, higher PUA …
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Y Lytvyn, M Škrtić, GK Yang, V Lai, JW Scholey, PM Yip… - Diabetic Medicine, 2016