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The aim of this study was to evaluate the analgesic effect of the methanolic extract from callus culture of Phyllanthus tenellus, P. corcovadensis and P. niruri in several models of pain in mice. The extracts (medium containing 2,4‐dichlorophenoxyacetic acid) of P. corcovadensis, P. niruri and P. tenellus (3–90 mg kg⁻¹, i.p.) caused graded inhibition of abdominal constrictions induced by acetic acid (0·6%), with ID50 (i.e. dose that reduced response of control by 50%) values of about 30, 19 and >30 mg kg⁻¹, respectively. The extract of callus of Phyllanthus obtained in indole‐3‐butyric acid and indole‐3‐acetic acid media (3–90 mg kg⁻¹, i.p.) caused a similar analgesic effect. In the formalin test, the extract of P. tenellus obtained in indole butyric acid medium (3–100 mg kg⁻¹, i.p.) inhibited only the second phase of formalin‐induced pain with an ID50 value of about 100 mg kg⁻¹. Both the indole acetic acid and indole …