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The mechanisms involved in bradykinin (BK)‐induced oedema in the rat paw as well as the interactions between BK and several inflammatory mediators, have been investigated.

Intraplantar injection of BK (1 nmol/paw) in rats pretreated with captopril (5 mg kg⁻¹, s.c.) caused a small amount of oedema formation (0.17 ± 0.05 ml). Des‐Arg⁹‐BK (DABK, a selective B₁ receptor agonist) up to 300 nmol/paw caused minimal oedema (0.03 ± 0.01 ml).

Co‐administration of prostaglandin E₂ (PGE₂), prostaglandin I₂ (PGI₂), calcitonin gene‐related peptide (CGRP), 5‐hydroxytryptamine (5‐HT), substance P (SP) or platelet activating factor (PAF) (1 pmol–1 nmol/paw) with BK (1 nmol/paw) dose‐dependently potentiated BK‐induced paw oedema. The rank order of potency (mean ED₅₀, pmol/paw) for this effect was: SP (8.1) > PAF (13.7) > PGI₂ (20.5) > 5‐HT (23.8) > CGRP (25.7) > PGE₂ (52.0). Co‐administration of …